What Will the Constellations Look Like in 50,000 Years? Part answers a question I had in Crete. The constellations do move around, but the ones that really change are the ones made up of stars in coincidental alignment rather than ones in the same system.
So, early man may well have looked at substantially different stars to the ones we see now. Certainly, it will be harder to see why the constellations got the names they did in the future.